3-Propylaniline → HCID 19829931、化合物

HRID 703808

反応式

HRID 703808 の反応式
[CH2:1]([C:4]1[CH:5]=[C:6]([CH:8]=[CH:9][CH:10]=1)[NH2:7])[CH2:2][CH3:3].C(=O)(O)[O-].[Na+].Cl[CH2:17][C:18]([O:20][CH3:21])=[O:19]>CCOCC>[CH3:21][O:20][C:18](=[O:19])[CH2:17][NH:7][C:6]1[CH:8]=[CH:9][CH:10]=[C:4]([CH2:1][CH2:2][CH3:3])[CH:5]=1

参加物

5

反応物 3

HCID 60563-PropylanilineHCID 7295Methyl chloroacetateHCID 516892Sodium Bicarbonate

生成物 1

HCID 19829931HCID 19829931、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 3-propylaniline (20 g), sodium bicarbonate (24.9 g) and methyl chloroacetate (24.0 g) were stirred under nitrogen at 80°-90° for 24 h. The cooled reaction mixture was poured into ether (100 ml) and filtered. The filtrate was washed with water (100 ml), dilute hydrochloric acid (100 ml) and water (100 ml), then dried and concentrated in vacuo. The oily product (21.2 g) was distilled to give the title compound as a liquid, b.p. 160° at 0.35 mmHg, which solidified to give a low melting solid (16.1 g).

後処理

  1. customThe cooled reaction mixture
  2. filtrationfiltered
  3. washThe filtrate was washed with water (100 ml), dilute hydrochloric acid (100 ml) and water (100 ml)
  4. customdried
  5. concentrationconcentrated in vacuo
  6. distillationThe oily product (21.2 g) was distilled

出典と根拠

ORDレコード
ord-5ececdb4c7464b4fa84b2a2e2cfb8931
出典データセット
uspto-grants-1991_01
特許番号
US04985427

関連ノート

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