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Chlorobenzene → 2-(Benzylthio)-7-hydroxy-5H-1,3,4-thiadiazolo(3,2-a)pyrimidin-5-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chlorobenzene | HCID 7964 | — |
| 反応物 | 1,3,4-Thiadiazol-2-amine, 5-((phenylmethyl)thio)- | HCID 99285 | — |
| 反応物 | Bis(2,4,6-trichlorophenyl) propanedioate | HCID 2783450 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 2-(Benzylthio)-7-hydroxy-5H-1,3,4-thiadiazolo(3,2-a)pyrimidin-5-one | HCID 135594371 | 98% |
反応手順
A mixture of 44.7 g of 2-amino-5-benzylthio-1,3,4-thiadiazole, 98.1 g of bis(2,4,6-trichlorophenyl) malonate and 140 ml of chlorobenzene was heated to 130°-140° C. and stirred for 20 minutes. After cooling, hexane was added to the mixture, and the formed precipitate was separated by filtration. The solid was washed with hexane and thus 57.1 g of 2-benzylthio-7-hydroxy-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one was obtained. Yield 98%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04985432 |
| 出典データセット | uspto-grants-1991_01 |
| ORD ID | ord-1f7a92d2e44a421793691518bc4b4866 |
| 出典メモ | uspto-grants-1991_01 |