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N-(Aminocarbonyl)-2-thiophenecarboxamide → 1-[1-(Naphth-2-ylmethyl)piperid-4-yl]-3-(then-2-oyl)urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(Aminocarbonyl)-2-thiophenecarboxamide | HCID 395032 | — |
| 反応物 | 4-Amino-1-(2-naphthyl)methylpiperidine | HCID 11195823 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 1-[1-(Naphth-2-ylmethyl)piperid-4-yl]-3-(then-2-oyl)urea | HCID 12942334 | — |
反応手順
4-Amino-1-(naphth-2-ylmethyl)piperidine (1.0 g, 0.0047 m) and 1-(then-2-oyl)urea (0.65 g, 0.0042 m) in pyridine (5 cm3) was refluxed for 9.5 hours. The solvent was evaporated, water added, and the precipitated title compound filtered and washed well with water. This was recrystallised from ethanol, converted to the hydrochloride salt in ethanol with ethanolic HCl, and recrystallised from ethanol, 0.5 g, at the hydrochloride, m.p. 217°-219° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04985438 |
| 出典データセット | uspto-grants-1991_01 |
| ORD ID | ord-e374e0a09e0a47fea24a78939de7697b |
| 出典メモ | uspto-grants-1991_01 |