2-Fluoro-4-nitroanisole → 3-Fluoro-4-methoxyaniline

HRID 703895

反応式

HRID 703895 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([F:12])[CH:5]=1)([O-])=O>O1CCOCC1.[C].[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([F:12])[CH:5]=1

参加物

4

反応物 1

HCID 2231042-Fluoro-4-nitroanisole

生成物 1

HCID 5811103-Fluoro-4-methoxyaniline収率 104.3%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒2 回HCID 312751,4-Dioxane溶媒

実験手順

[I] 2 g of 5% palladium carbon was added to a solution prepared by dissolving 10 g of 4-nitro-2-fluoroanisol in 150 ml of 1,4-dioxane, and the mixture was subjected to catalytic reduction under a hydrogen gas pressure of 4 kg/cm2 at room temperature for 30 minutes. After the completion of the reaction, palladium carbon was removed by filtration, and the solvent was distilled off under reduced pressure to obtain 8.6 g of 4-amino-2-fluoroanisol.

後処理

  1. customprepared
  2. customat room temperature
  3. customfor 30 minutes
  4. customwas removed by filtration
  5. distillationthe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-75e9e91173c2460e983b1c6c1afaf4e5
出典データセット
uspto-grants-1991_01
特許番号
US04985449

関連ノート

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