4-(Bromomethyl)benzonitrile → cis-2-[(4-Chlorobenzenesulfonyl)-(4-cyano-benzyl)-amino]-cyclohexanecarboxylic acid amide

HRID 7039

反応式

HRID 7039 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C@H:12]2[CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]2[C:18]([NH2:20])=[O:19])(=[O:10])=[O:9])=[CH:4][CH:3]=1.Br[CH2:22][C:23]1[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][CH:24]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH2:22][C:23]2[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][CH:24]=2)[C@H:12]2[CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]2[C:18]([NH2:20])=[O:19])(=[O:9])=[O:10])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 869964-(Bromomethyl)benzonitrileHCID 69655699cis-2-(4-Chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide

生成物 1

HCID 69655995cis-2-[(4-Chlorobenzenesulfonyl)-(4-cyano-benzyl)-amino]-cyclohexanecarboxylic acid amide収率 49%

実験手順

The titled compound (133 mg) was prepared in 49% yield from cis-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide and 4-bromomethyl-benzonitrile according to the procedure described in Example 11: 1H NMR (DMSO-d6) δ 7.84 (d, 2 H, J=8.0 Hz), 7.73 (d, 2 H, J=8.0 Hz), 7.66 (d, 2 H,J=8.0 Hz), 7.48 (d, 2 H,J=8.0 Hz), 7.29 (s, 1 H), 6.60 (s, 1 H), 4.63 (AB2,2 H,Δv=16,Jab=76 Hz), 3.84 (m, 1 H), 2.79 (m, 1 H), 2.41 (m, 1 H), 1.64 (m, 2 H), 1.27 (m, 3 H), 0.85 (m, 1 H); MS m/e 454.02 (M+Na)+.

出典と根拠

ORDレコード
ord-83b1b572c4fe4e0f8bef16bc986afbb0
出典データセット
uspto-grants-2006_08
特許番号
US07084178B2

関連ノート

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