Ammonia → 7-Amino-4,4-dimethyl-3,4-dihydroquinolin-2(1H)-one

HRID 703925ノート

反応式

HRID 703925 の反応式
C([NH:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9]([CH3:17])([CH3:16])[CH2:10][C:11](=[O:15])[NH:12]2)=[CH:7][CH:6]=1)(=O)C.Cl.N>C(O)C>[NH2:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9]([CH3:17])([CH3:16])[CH2:10][C:11](=[O:15])[NH:12]2)=[CH:7][CH:6]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 14476477N-(4,4-dimethyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)acetamide

生成物 1

HCID 144764787-Amino-4,4-dimethyl-3,4-dihydroquinolin-2(1H)-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A suspension of 23.2 g. (0.1 mole) 7-acetamido-1,2,3,4-tetrahydro-4,4-dimethylquinolin-2-one, 200 ml. ethanol and 20 ml. concentrated hydrochloric acid is boiled under reflux until dissolving is complete. The pH value is then adjusted with ammonia to 8, the reaction mixture is extracted three times with dichloromethane and the organic phase is dried over anhydrous sodium sulphate and freed from solvent. Yield 13.1 g. (69% of theory); m.p. 161°-163° C.

後処理

  1. additionA suspension of 23.2 g
  2. temperatureunder reflux
  3. dissolutionuntil dissolving
  4. extractionthe reaction mixture is extracted three times with dichloromethane
  5. dry with materialthe organic phase is dried over anhydrous sodium sulphate

出典と根拠

ORDレコード
ord-6a0695c6cac449ae9e80780588ce1b26
出典データセット
uspto-grants-1991_01
特許番号
US04985448

反応ノート

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