Hydrochloric Acid → 3-(3-Carboxy-2-oxo-1,2-dihydropyridin-5-yl)-2-phenylpyrazolo[1,5-a]pyridine

反応式

C(C1[C:4](=[O:24])[NH:5][CH:6]=[C:7]([C:9]2[C:10]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[N:11][N:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=23)[CH:8]=1)#N.[OH-:25].[K+].Cl.[CH2:28]([OH:30])[CH3:29]>>[C:28]([C:29]1[C:4](=[O:24])[NH:5][CH:6]=[C:7]([C:9]2[C:10]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[N:11][N:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=23)[CH:8]=1)([OH:25])=[O:30]

参加物

反応物 4

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 14797Potassium Hydroxide

HCID 151581163-(3-Cyano-2-oxo-1,2-dihydropyridin-5-yl)-2-phenylpyrazolo[1,5-a]pyridine

生成物 1

HCID 151581293-(3-Carboxy-2-oxo-1,2-dihydropyridin-5-yl)-2-phenylpyrazolo[1,5-a]pyridine

実験手順

A mixture of 3-(3-cyano-2-oxo-1,2-dihydropyridin-5-yl)-2-phenylpyrazolo[1,5-a]pyridine (0.60 g) and 85% potassium hydroxide (0.38 g) in 67% aqueous ethanol (6 ml) was refluxed for 4 hours. After cooling, the reaction mixture was added onto ice (12 g) and acidified with 5% hydrochloric acid. Precipitates were collected and recrystallized from a mixture of N,N-dimethylformamide and water twice to give 3-(3-carboxy-2-oxo-1,2-dihydropyridin-5-yl)-2-phenylpyrazolo[1,5-a]pyridine (0.36 g).