1,1,1-Trimethoxy-2-methylpropane → N-(1-Methoxy-2-methylpropylidene)-3-(2-methylphenyl)-1,2,4-thiadiazole-5-sulfonamide

HRID 704030ノート

反応式

HRID 704030 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]=[C:11]([S:13]([NH2:16])(=[O:15])=[O:14])[S:10][N:9]=1.[C:17](OC)(OC)([O:21][CH3:22])[CH:18]([CH3:20])[CH3:19]>CCCCCC>[CH3:22][O:21][C:17](=[N:16][S:13]([C:11]1[S:10][N:9]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[CH3:1])[N:12]=1)(=[O:15])=[O:14])[CH:18]([CH3:20])[CH3:19]

参加物

4

反応物 2

HCID 404951,1,1-Trimethoxy-2-methylpropaneHCID 141831333-(2-Methylphenyl)-1,2,4-thiadiazole-5-sulfonamide

生成物 1

HCID 54509802N-(1-Methoxy-2-methylpropylidene)-3-(2-methylphenyl)-1,2,4-thiadiazole-5-sulfonamide

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

A mixture of 3 g of 3-(2-methylphenyl)-1,2,4-thiadiazole-5-sulfonamide and 11 ml of trimethyl orthoisobutyrate was heated to reflux and stirred for 2 hours. The mixture was allowed to cool to room temperature, whereupon a precipitate formed. Hexane was added and the mixture was stirred for 15 minutes. The solid was filtered and washed with hexane and dried in vacuum (P2O5) to give 3.49 g of solid, m.p. 116°-118°.

後処理

  1. temperaturewas heated
  2. temperatureto reflux
  3. customformed
  4. stirringthe mixture was stirred for 15 minutes
  5. filtrationThe solid was filtered
  6. washwashed with hexane
  7. dry with materialdried in vacuum (P2O5)

出典と根拠

ORDレコード
ord-6455b4f259a141abbf05e8610918c59f
出典データセット
uspto-grants-1991_01
特許番号
US04985450

反応ノート

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