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1-Piperazinecarboxaldehyde → 4-(4-Methylpyridazino[4,5-b]indolizin-1-yl)-piperazinecarboxaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Piperazinecarboxaldehyde | HCID 82191 | — |
| 反応物 | 1-Chloro-4-methylpyridazino[4,5-b]indolizine | HCID 15713312 | — |
| 生成物 | 4-(4-Methylpyridazino[4,5-b]indolizin-1-yl)-piperazinecarboxaldehyde | HCID 15713337 | — |
反応手順
Following the procedure of Example 1, reaction of one equivalent of 1-chloro-4-methylpyridazino[4,5-b]indolizine and 10 equivalents of piperazinecarboxaldehyde at 150° C. gave the title compound as the free base, which was purified by flash chromatography (silica gel, 1 to 20% methanol:ethyl acetate) and converted to the dihydrochloride salt (MeOH/etheral HCl/diethyl ether), mp 325° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04985560 |
| 出典データセット | uspto-grants-1991_01 |
| ORD ID | ord-8d64ab1e5902489abae5d19b42e1f524 |
| 出典メモ | uspto-grants-1991_01 |