4-Chloro-2-fluoro-5-(pentyloxycarbonylmethyloxy)nitrobenzene → 4-Chloro-2-fluoro-5-(pentyloxycarbonylmethyloxy)aniline

HRID 704091

反応式

HRID 704091 の反応式
[H][H].[Cl:3][C:4]1[C:9]([O:10][CH2:11][C:12]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[O:13])=[CH:8][C:7]([N+:20]([O-])=O)=[C:6]([F:23])[CH:5]=1>[C].[Pd].C1(C)C=CC=CC=1>[Cl:3][C:4]1[C:9]([O:10][CH2:11][C:12]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[O:13])=[CH:8][C:7]([NH2:20])=[C:6]([F:23])[CH:5]=1

参加物

5

反応物 2

HCID 146178494-Chloro-2-fluoro-5-(pentyloxycarbonylmethyloxy)nitrobenzeneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 146178504-Chloro-2-fluoro-5-(pentyloxycarbonylmethyloxy)aniline収率 62.1%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 1140Toluene溶媒

実験手順

Hydrogen gas (1.3 liters) was introduced into a mixture of the compound (III) (6.4 g), 5% palladium-carbon (0.32 g) and toluene (64 g) at room temperature while stirring in 1 hour. After removal of the catalyst from the reaction mixture, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography to give 4-chloro-2-fluoro-5-(pentyloxycarbonylmethyloxy)aniline (3.6 g).

後処理

  1. customAfter removal of the catalyst from the reaction mixture
  2. customthe solvent was removed under reduced pressure
  3. customthe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-656a2b2c6c0e4954967fca7975248aa6
出典データセット
uspto-grants-1991_01
特許番号
US04985570

関連ノート

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