Acetic Acid → Flumiclorac-pentyl

HRID 704095

反応式

HRID 704095 の反応式
[Cl:1][C:2]1[C:8]([O:9][CH2:10][C:11]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])=[O:12])=[CH:7][C:5]([NH2:6])=[C:4]([F:19])[CH:3]=1.[C:20]([OH:23])(=O)[CH3:21]>O>[Cl:1][C:2]1[C:8]([O:9][CH2:10][C:11]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])=[O:12])=[CH:7][C:5]([N:6]2[C:20](=[O:23])[C:21]3[CH2:2][CH2:3][CH2:4][CH2:5][C:7]=3[C:8]2=[O:9])=[C:4]([F:19])[CH:3]=1

参加物

4

反応物 2

HCID 176Acetic AcidHCID 146178504-Chloro-2-fluoro-5-(pentyloxycarbonylmethyloxy)aniline

生成物 1

HCID 443048Flumiclorac-pentyl収率 175.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of the compound (II) (12.0 g), 3,4,5,6-tetarhydrophthalic anhydride (7.56 g) and acetic acid (50 g) was heated under reflux for 2 hours. The reaction mixture was cooled to room temperature, and water (75 g) was added thereto. The precipitated crystals were collected by filtration to give the compound (I) (15.4 g).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. filtrationThe precipitated crystals were collected by filtration

出典と根拠

ORDレコード
ord-ede6506e630c45878393723ffbf3599d
出典データセット
uspto-grants-1991_01
特許番号
US04985570

関連ノート

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