7a-nitromethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine → (Hexahydro-1H-pyrrolizin-7A-YL)methanamine

関与物質

反応条件

反応手順

To a suspension of Raney nickel (300 mg) in 5.0 ml of ethanol, 7a-nitromethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine (300 mg, 1.76 mmol, obtained in Example 1) was added and the resulting mixture was stirred for 1 hour at 20° C. under hydrogen atmosphere. The catalyst was filtered off, the filtrate was concentrated, and the resulting crude product was distilled in vacuo to afford 185 mg of the desired compound (Yield: 75%).

情報源と証拠