Fumaric Acid → HCID 20074838、化合物
反応式
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[CH:9]1([CH2:13][NH:14][C:15]([C:17]2[CH:30]=[CH:29][C:28]3[S:27][C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[N:20]([CH:31]([CH3:38])[CH2:32][N:33]4[CH2:37][CH2:36][CH2:35][CH2:34]4)[C:19]=3[CH:18]=2)=[S:16])[CH2:12][CH2:11][CH2:10]1>CC(O)C>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[CH:9]1([CH2:13][NH:14][C:15]([C:17]2[CH:30]=[CH:29][C:28]3[S:27][C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[N:20]([CH:31]([CH3:38])[CH2:32][N:33]4[CH2:34][CH2:35][CH2:36][CH2:37]4)[C:19]=3[CH:18]=2)=[S:16])[CH2:12][CH2:11][CH2:10]1参加物
4
実験手順
A solution of fumaric acid (0.58 g) in 2-propanol (14 cc) under reflux is added to a solution of N-cyclobutylmethyl-10-[1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarbothioamide, L series (2.19 g) in 2-propanol (16 cc) under reflux. After cooling, the mixture is concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 40° C. and the residue is taken up with stirring for 16 hours with isopropyl ether (70 cc). The suspension obtained is filtered and the solid is dried under reduced pressure (5 mm Hg; 4 kPa) at 50° C. and dissolved in 2-propanol under reflux (50 cc). After cooling, the product crystallizes and stirring is continued for 16 hours at 20° C. The crystals are filtered off and dried under reduced pressure (5 mm Hg; 4 kPa) at 50° C. N-Cyclobutylmethyl-10-[1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarbothioamide fumarate, L series (1.52 g) is thereby obtained in the form of yellow crystals, m.p. 194° C.