反応式
Cl.[N:2]1([CH2:7][CH:8]([N:10]2[C:23]3[CH:22]=[C:21]([C:24](Cl)=[O:25])[CH:20]=[CH:19][C:18]=3[S:17][C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH3:9])[CH2:6][CH2:5][CH2:4][CH2:3]1.[CH:27]1([CH2:30][NH2:31])[CH2:29][CH2:28]1>ClCCl>[CH:27]1([CH2:30][NH:31][C:24]([C:21]2[CH:20]=[CH:19][C:18]3[S:17][C:16]4[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=4)[N:10]([CH:8]([CH3:9])[CH2:7][N:2]4[CH2:6][CH2:5][CH2:4][CH2:3]4)[C:23]=3[CH:22]=2)=[O:25])[CH2:29][CH2:28]1参加物
実験手順
By working in a manner similar to that described below in Example 103, but starting with 10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarbonyl chloride hydrochloride (3.5 g) in dichloromethane (100 cc) and with cyclopropylmethylamine (3.8 g), N-(cyclopropylmethyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide (3 g) is obtained in the form of a cream-coloured product of meringue-like consistency, which is dissolved in acetonitrile (20 cc). A 2.4N solution (8 cc) of hydrochloric acid in ethyl ether is then added. The crystals are drained and dried under reduced pressure (5 mm Hg; 0.67 kPa) at 40° C. N-(Cyclopropylmethyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide hydrochloride (2.6 g) is obtained in the form of white crystals, m.p. 220° C.
出典と根拠
- ORDレコード
- ord-472369dfaef54815a64fdee4ab179027
- 出典データセット
- uspto-grants-1991_01
- 特許番号
- US04985419
関連ノート
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