Cyclobutylmethylamine → N-cyclobutylmethyl-10-[(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide

HRID 704236

反応式

HRID 704236 の反応式
Cl.[N:2]1([CH2:7][CH:8]([N:10]2[C:23]3[CH:22]=[C:21]([C:24](Cl)=[O:25])[CH:20]=[CH:19][C:18]=3[S:17][C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH3:9])[CH2:6][CH2:5][CH2:4][CH2:3]1.[CH:27]1([CH2:31][NH2:32])[CH2:30][CH2:29][CH2:28]1>ClCCl>[CH:27]1([CH2:31][NH:32][C:24]([C:21]2[CH:20]=[CH:19][C:18]3[S:17][C:16]4[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=4)[N:10]([CH:8]([CH3:9])[CH2:7][N:2]4[CH2:6][CH2:5][CH2:4][CH2:3]4)[C:23]=3[CH:22]=2)=[O:25])[CH2:30][CH2:29][CH2:28]1

参加物

4

反応物 2

HCID 409746CyclobutylmethylamineHCID 2007488610-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarbonyl chloride hydrochloride

生成物 1

HCID 15096214N-cyclobutylmethyl-10-[(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide収率 48.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

By working in a manner similar to that described below in Example 103, but starting with 10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarbonyl chloride hydrochloride (3.4 g) in dichloromethane (100 cc) and with cyclobutylmethylamine (4.5 g), N-(cyclobutylmethyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide (1.7 g) is obtained, after recrystallization in isopropyl ether, in the form of white crystals, m.p. 133° C.

出典と根拠

ORDレコード
ord-06a5e37eb5e34ec6b94a8ab08fc66f06
出典データセット
uspto-grants-1991_01
特許番号
US04985419

関連ノート

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