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(2-Nitrophenyl)methanamine → N-(2-nitrobenzyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2-Nitrophenyl)methanamine | HCID 423893 | — |
| 反応物 | 10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarbonyl chloride hydrochloride | HCID 20074886 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(2-nitrobenzyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide | HCID 20074883 | 36.9% |
反応手順
By working in a manner similar to that described in Example 103, but starting with 10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarbonyl chloride hydrochloride (2.5 g) in dichloromethane (50 cc) and with 2-nitrobenzylamine (2.1 g), N-(2-nitrobenzyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide (1.1 g) is obtained, after recrystallization in isopropyl ether, in the form of yellow crystals, m.p. 95° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04985419 |
| 出典データセット | uspto-grants-1991_01 |
| ORD ID | ord-6cd4e6c7cb5a4544b493d586f7f756f4 |
| 出典メモ | uspto-grants-1991_01 |