Hydrochloric Acid → HCID 178463985、化合物
反応式
[ClH:1].[CH2:2]([NH:9][C:10]([C:12]1[CH:25]=[CH:24][C:23]2[S:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]([CH:26]([CH3:33])[CH2:27][N:28]([CH2:31][CH3:32])[CH2:29][CH3:30])[C:14]=2[CH:13]=1)=[NH:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>CC(C)=O>[ClH:1].[ClH:1].[CH2:2]([NH:9][C:10]([C:12]1[CH:25]=[CH:24][C:23]2[S:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]([CH:26]([CH3:33])[CH2:27][N:28]([CH2:31][CH3:32])[CH2:29][CH3:30])[C:14]=2[CH:13]=1)=[NH:11])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1参加物
4
反応条件
- 温度
- 25 °C
実験手順
A 3.5N acetone solution (1.42 cc) of hydrocloric acid is added dropwise to an acetone solution (11 cc) of N-benzyl-10-[(2RS)-1-diethylamino-2-propyl]-2-phenothiazinecarboxamidine (0.74 g). The mixture is stirred for 3 hours at 25° C. and then concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 50° C. The residue is taken up in ethyl ether (50 cc) and the suspension is kept stirred for 3 hours at 25° C. The solid is filtered off on sintered glass, washed with ethyl ether (2×5 cc) and dried for 12 hours under reduced pressure (5 mm Hg; 0.7 kPa) to give N-benzyl-10-[(2RS)-1-diethylamino-2-propyl]-2-phenothiazinecarboxamidine dihydrochloride (0.76 g), m.p. 206°-207° C.