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4-(Bromomethyl)benzonitrile → trans-2-[(4-Chlorobenzenesulfonyl)-(4-cyano-benzyl)-amino]-cyclohexanecarboxylic acid amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Bromomethyl)benzonitrile | HCID 86996 | — |
| 反応物 | trans-2-(4-Chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide | HCID 69656245 | — |
| 生成物 | trans-2-[(4-Chlorobenzenesulfonyl)-(4-cyano-benzyl)-amino]-cyclohexanecarboxylic acid amide | HCID 11247468 | 43% |
反応手順
The titled compound was prepared in 43% yield from trans-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide and 4-bromomethyl-benzonitrile according to the procedure described in Example 11: 1H NMR (DMSO-d6) δ 7.71(m, 4 H), 7.53 (m, 4 H), 7.29 (s, 1 H), 6.76 (s, 1 H), 4.44 (AB2,2 H,Δv=16,Jab=84 Hz), 3.96 (m, 1 H), 1.80 (m, 1 H), 1.57 (m, 3 H), 1.17 (m, 5 H); MS m/e 432.01 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07084178B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-386f48eba40548c182cc938b1a8dd1e7 |
| 出典メモ | uspto-grants-2006_08 |