Formic Acid → 3-(2-Thienyl)piperazine-2,5-dione
反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]([NH:11][C:12](=[O:22])[CH2:13][NH:14][C:15](OC(C)(C)C)=[O:16])C(OC)=O.C(O)=O>C1(C)C=CC=CC=1.C(O)CCC>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[NH:11][C:12](=[O:22])[CH2:13][NH:14][C:15]1=[O:16]参加物
5
実験手順
A mixture of 6.4 g of methyl 2-thienyl-N-(tert.-butoxycarbonylaminoacetyl)aminoacetate and 200 ml of formic acid is stirred at room temperature for 15 h. The volatile fractions are stripped off in vacuo, and the residue is heated to boiling in a mixture of 80 ml of toluene and 300 ml of butanol under reflux for 3 h. The solvents are then removed in a rotary evaporator, and the residue is recrystallized from methanol.
後処理
- temperaturethe residue is heated
- temperatureunder reflux for 3 h
- customThe solvents are then removed in a rotary evaporator
- customthe residue is recrystallized from methanol
出典と根拠
- ORDレコード
- ord-6193f14686304ddeb58d632a033544b9
- 出典データセット
- uspto-grants-1991_01
- 特許番号
- US04987134
反応ノート
読み込み中…