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1-(3-Methyl-3-phenylbutyl)-4-[2-(3-pyridyl)thiazolidin-4-ylcarbonyl]piperazine → YM 264
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(3-Methyl-3-phenylbutyl)-4-[2-(3-pyridyl)thiazolidin-4-ylcarbonyl]piperazine | HCID 131436 | — |
| 反応物 | Fumaric Acid | HCID 444972 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | YM 264 | HCID 6439322 | 72.5% |
反応手順
To a solution of 1-(3-methyl-3-phenylbutyl)-4[2-(3-pyridyl)thiazolidin-4-ylcarbonyl]piperazine (1.22 g) in ethanol (6 ml) was added fumaric acid (0.32 g) and the mixture was dissolved. The solution was stirred at room temperature for 2 hours and allowed to stand at room temperature for a day. The resultant crystals were collected by filtration, washed with ethanol and then dried to give 1.08 g of 1-(3-methyl-3-phenylbutyl]-4-[2-(3-pyridyl)thiazolidin-4-ylcarbonyl]piperazine fumarate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04987132 |
| 出典データセット | uspto-grants-1991_01 |
| ORD ID | ord-88b7f8b58e1348cf9f62240b69c336cd |
| 出典メモ | uspto-grants-1991_01 |