2-Benzyl-5,6-dimethoxyisoindoline → 5,6-Dimethoxyisoindoline
反応式
C([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([O:19][CH3:20])=[C:13]([O:17][CH3:18])[CH:14]=2)[CH2:9]1)C1C=CC=CC=1>CO.[C].[Pd]>[CH3:18][O:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[O:19][CH3:20])[CH2:9][NH:8][CH2:16]2参加物
4
実験手順
1.20 g (4.46 mmol) of 2-benzyl-5,6-dimethoxyisoindoline was dissolved in 40 ml of methanol at 40° C., and 84 mg of 10% palladium carbon was added thereto. Under a hydrogen stream, catalytic reduction was conducted at the same temperature for 4 hours. The solvent was distilled off under reduced pressure, and a small amount of ethyl acetate and diethylether was added to the residue and stirred. The precipitates were collected to obtain 617 mg (yield: 77.3%) of the above identified compound.
後処理
- distillationThe solvent was distilled off under reduced pressure
- additiona small amount of ethyl acetate and diethylether was added to the residue
- customThe precipitates were collected
- customto obtain 617 mg (yield: 77.3%) of the
出典と根拠
- ORDレコード
- ord-ad7730c17b25490ab447e050783a9c6c
- 出典データセット
- uspto-grants-1991_01
- 特許番号
- US04987235
反応ノート
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