Hydrochloric Acid → 5,6-dimethoxy-2,3-dihydro-1H-isoindole hydrochloride
反応式
C([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([O:19][CH3:20])=[C:13]([O:17][CH3:18])[CH:14]=2)[CH2:9]1)C1C=CC=CC=1.[ClH:21]>CO.[C].[Pd]>[ClH:21].[CH3:18][O:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[O:19][CH3:20])[CH2:9][NH:8][CH2:16]2参加物
5
実験手順
1.00 g (3.72 mmol) of 2-benzyl-5,6-dimethoxyisoindoline was dissolved in 50 ml of methanol at 40° C., and then 1.24 g (7.44 mmol) of 6N hydrochloric acid and 70 mg of 10% palladium carbon were added thereto. Under a hydrogen gas stream, catalytic reduction was conducted at the same temperature. The solvent was distilled off under reduced pressure, and the crystalline residue was washed with acetone to obtain 758 mg (yield: 94.3%) of the above identified compound as colorless prism crystals.
後処理
- distillationThe solvent was distilled off under reduced pressure
- washthe crystalline residue was washed with acetone
- customto obtain 758 mg (yield: 94.3%) of the
出典と根拠
- ORDレコード
- ord-d9811e2d818d4c0bb51f48c7003af726
- 出典データセット
- uspto-grants-1991_01
- 特許番号
- US04987235
反応ノート
読み込み中…