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Water → Flumiclorac-pentyl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Acetic acid, chloro-, pentyl ester | HCID 138488 | — |
| 反応物 | 1H-Isoindole-1,3(2H)-dione, 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-4,5,6,7-tetrahydro- | HCID 158651 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Flumiclorac-pentyl | HCID 443048 | 41.9% |
反応手順
To a solution of N-(4-chloro-2-fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydrophthalimide (3 g) in dimethylformamide (100 ml), anhydrous potassium carbonate (0.8 g) and then amyl chloroacetate (1.9 g) were added, and the resultant mixture was heated at 70° to 80° C. for 3 hours. The reaction mixture was cooled to room temperature, admixed with water and extracted with diethyl ether. The etheral layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the compound (I) (1.8 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04987247 |
| 出典データセット | uspto-grants-1991_01 |
| ORD ID | ord-bb48b08d53464722af404f6191c5acdf |
| 出典メモ | uspto-grants-1991_01 |