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1-Chloro-6,7-dimethoxyisoquinoline → 6-[4-(6,7-dimethoxyisoquinolin-1-yl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Chloro-6,7-dimethoxyisoquinoline | HCID 10640708 | — |
| 反応物 | 6-(piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one | HCID 11117896 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 溶媒 | 6-[4-(2-tert-Butoxycarbonylamino-4-methylthiazole-5-carbonyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone | HCID 20072891 | — |
| 生成物 | 6-[4-(6,7-dimethoxyisoquinolin-1-yl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone | HCID 20072787 | 37.3% |
反応手順
1-Chloro-6,7-dimethoxyisoquinoline (0.63 g) and 6-(1-piperazinyl)-3,4-dihydro-2(1H)-quinolinone (1.30 g) were mixed at 200° C. for 1.5 hours under stirring. The mixture was dissolved in a mixture of chloroform and methanol (10:1 V/V) and subjected to a column chromatography on silica gel (eluent:methanol in chloroform, 0-2% V/V). The fractions containing the object compound were combined and concentrated and the residue was triturated with diisopropyl ether to give 6-[4-(6,7-dimethoxyisoquinolin-1-yl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone (0.44 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04988698 |
| 出典データセット | uspto-grants-1991_01 |
| ORD ID | ord-130cfb6250e6439a9b4430a99d55c35f |
| 出典メモ | uspto-grants-1991_01 |