6-[4-(2-tert-Butoxycarbonylamino-4-methylthiazole-5-carbonyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone → 6-[4-(2-amino-4-methylthiazole-5-carbonyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone

HRID 704635

反応式

HRID 704635 の反応式
C(OC([NH:8][C:9]1[S:10][C:11]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:24]=[C:25]4[C:30](=[CH:31][CH:32]=3)[NH:29][C:28](=[O:33])[CH2:27][CH2:26]4)[CH2:19][CH2:18]2)=[O:16])=[C:12]([CH3:14])[N:13]=1)=O)(C)(C)C>C(O)=O>[NH2:8][C:9]1[S:10][C:11]([C:15]([N:17]2[CH2:18][CH2:19][N:20]([C:23]3[CH:24]=[C:25]4[C:30](=[CH:31][CH:32]=3)[NH:29][C:28](=[O:33])[CH2:27][CH2:26]4)[CH2:21][CH2:22]2)=[O:16])=[C:12]([CH3:14])[N:13]=1

参加物

3

反応物 1

HCID 200728916-[4-(2-tert-Butoxycarbonylamino-4-methylthiazole-5-carbonyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone

生成物 1

HCID 200727936-[4-(2-amino-4-methylthiazole-5-carbonyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone収率 95.2%

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

6-[4-(2-tert-Butoxycarbonylamino-4-methylthiazole-5-carbonyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone (1.2 g) was dissolved in formic acid (25 ml) and the solution was stirred for 4 hours at ambient temperature. After the solvent was removed, ethyl acetate (10 ml) and water (10 ml) was added to the residue and the mixture was adjusted to pH 4.5 with 10% aqueous solution of potassium carbonate. The resulting precipitate was collected and recrystallized from methanol-water to give 6-[4-(2-amino-4-methylthiazole-5-carbonyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone (0.9 g).

後処理

  1. customAfter the solvent was removed
  2. additionethyl acetate (10 ml) and water (10 ml) was added to the residue
  3. customThe resulting precipitate was collected
  4. customrecrystallized from methanol-water

出典と根拠

ORDレコード
ord-5682d432bcc64531b954917cebff8033
出典データセット
uspto-grants-1991_01
特許番号
US04988698

関連ノート

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