1-[4-(Bromomethyl)Phenyl]-1H-Pyrazole → cis-2-[(4-Chlorobenzenesulfonyl)-(4-pyrazol-1-yl-benzyl)-amino]-cycloheptanecarboxylic acid amide

関与物質

反応手順

The titled compound (40 mg) was prepared in 18% yield from cis-2-(4-chlorobenzenesulfonylamino)-cycloheptanecarboxylic acid amide (150 mg, 0.45 mmol) and 1-(4-bromomethyl-phenyl)-1H-pyrazole according to the N-alkylation procedure described in Example 11: 1H NMR (DMSO-d6) δ 8.46 (s, 1 H), 7.79 (d, 2 H, J=12.0 Hz), 7.71 (m, 3 H), 7.62 (d, 2 H, J=8.0 Hz), 7.40 (d, 2 H), J=8.0 Hz), 7.33 (s br, 1 H), 6.70 (s br, 1 H), 6.54 (s, 1 H), 4.56 (AB2,2 H,Δv=16,Jab=96 Hz), 4.00 (m, 1 H), 2.78 (m, 1 H), 2.30 (m, 1 H), 1.73 (m, 2 H), 1.37 (m, 7 H); MS m/e 509.12 (M+Na)+.

情報源と証拠