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N,N-Diethyl-1,3-propanediamine → N-[3-(diethylamino)propyl]-4,5-bis(4-fluorophenyl)-1H-pyrazole-1-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N-Diethyl-1,3-propanediamine | HCID 61011 | — |
| 反応物 | ethyl 4,5-bis(4-fluorophenyl)-1H-pyrazole-1-acetate | HCID 14699554 | — |
| 生成物 | N-[3-(diethylamino)propyl]-4,5-bis(4-fluorophenyl)-1H-pyrazole-1-acetamide | HCID 20073281 | 45.4% |
反応手順
By a procedure substantially similar to that of Example 14, 8 g (0.023 mol) of ethyl 4,5-bis(4-fluorophenyl)-1H-pyrazole-1-acetate of Example 3 and 34.3 mL (0.22 mol) of diethylaminopropylamine were reacted to produce 4.45 g of N-[3-(diethylamino)propyl]-4,5-bis(4-fluorophenyl)-1H-pyrazole-1-acetamide. The solid product after trituration in water collapsed to a non-crystalline, white, waxy solid upon drying.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04988725 |
| 出典データセット | uspto-grants-1991_01 |
| ORD ID | ord-d3b6380771a74693b629e5a61c38f691 |
| 出典メモ | uspto-grants-1991_01 |