Hydrochloric Acid → 4-Quinolinamine, 2-chloro-N-(2-methylpropyl)-3-nitro-

HRID 704848ノート

反応式

HRID 704848 の反応式
[Cl:1][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.C(N(CC)CC)C.[CH3:23][CH:24]([CH3:27])[CH2:25][NH2:26].Cl>CN(C)C=O>[Cl:1][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[C:10]([NH:26][CH2:25][CH:24]([CH3:27])[CH3:23])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6558IsobutylamineHCID 8471TriethylamineHCID 27851382,4-Dichloro-3-nitroquinoline

生成物 1

HCID 109348134-Quinolinamine, 2-chloro-N-(2-methylpropyl)-3-nitro-収率 90%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
0 °C

実験手順

A mixture of 2,4-dichloro-3-nitroquinoline (100 g) and N,N-dimethylformamide (180 mL) was stirred, and triethylamine (42 g, 4 eq) was added dropwise, followed by dropwise addition of 2-methylpropylamine (21.5 g, 0.7 eq). The mixture was stirred at room temperature until the reaction was completed as determined by gas chromatography. Aqueous hydrochloric acid (250 mL, 4N) was added with stirring. The resulting mixture was stirred and cooled to about 0° C. to precipitate the product. The precipitate was filtered, washed with water, and dried at reduced pressure to afford the product 2-chloro-N-(2-methylpropyl)-3-nitro-4-quinolinamine in about 90% yield.

後処理

  1. stirringThe mixture was stirred at room temperature until the reaction
  2. stirringwith stirring
  3. stirringThe resulting mixture was stirred
  4. customto precipitate the product
  5. filtrationThe precipitate was filtered
  6. washwashed with water
  7. customdried at reduced pressure

出典と根拠

ORDレコード
ord-919a4c5a9ee845f980bd4e7e70c3943e
出典データセット
uspto-grants-1991_01
特許番号
US04988815

反応ノート

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