関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethylenediamine | HCID 3301 | — |
| 反応物 | 1-Bromo-2-chlorobenzene | HCID 12754 | — |
| 試薬 | Sodium t-butoxide | HCID 23676156 | — |
| 触媒 | Phosphine, tris(4-methylphenyl)- | HCID 13956 | — |
| 触媒 | Palladium (II) acetate | HCID 4144353 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N'-(2-chlorophenyl)ethane-1,2-diamine | HCID 12666392 | 0% |
反応手順
Ref: R2239 To a mixture of 1-bromo-2-chlorobenzene (0.824 g, 4.30 mmol), tri-p- tolylphosphine (0.262 g, 0.86 mmol), sodium 2-methylpropan-2-olate (0.414 g, 4.30 mmol), diacetoxypalladium (0.097 g, 0.43 mmol) in toluene (4 mL) was added ethane-1,2-diamine (1.293 g, 21.52 mmol). The mixture was heated with microwave at 140 °C for 1 h. No product was formed.
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-5911a740f60145b0bc355f2a886b772f |
|---|
| 出典メモ | 750 AstraZeneca ELN dataset |
|---|
