反応式
[CH3:1][C@@:2]12[CH2:24][CH2:23][C@:22]3([CH3:25])[C:8](=[CH:9][C:10]([C@H:12]4[C@@:21]3([CH3:26])[CH2:20][CH2:19][C@@H:18]3[C@:13]4([CH3:54])[CH2:14][CH2:15][C@H:16]([O:29][C@H:30]4[O:35][C@H:34]([C:36]([OH:38])=[O:37])[C@@H:33]([OH:39])[C@H:32]([OH:40])[C@H:31]4[O:41][C@@H:42]4[O:47][C@H:46]([C:48]([OH:50])=[O:49])[C@@H:45]([OH:51])[C@H:44]([OH:52])[C@H:43]4[OH:53])[C:17]3([CH3:28])[CH3:27])=[O:11])[C@@H:7]1[CH2:6][C@:5]([C:56]([OH:58])=[O:57])([CH3:55])[CH2:4][CH2:3]2.[CH2:59]([NH2:62])[CH2:60][NH2:61].C1(N=C=NC2CCCCC2)CCCCC1>CN(C=O)C>[CH3:1][C@@:2]12[CH2:24][CH2:23][C@:22]3([CH3:25])[C:8](=[CH:9][C:10]([C@H:12]4[C@@:21]3([CH3:26])[CH2:20][CH2:19][C@@H:18]3[C@:13]4([CH3:54])[CH2:14][CH2:15][C@H:16]([O:29][C@H:30]4[O:35][C@H:34]([C:36]([OH:38])=[O:37])[C@@H:33]([OH:39])[C@H:32]([OH:40])[C@H:31]4[O:41][C@@H:42]4[O:47][C@H:46]([C:48]([OH:50])=[O:49])[C@@H:45]([OH:51])[C@H:44]([OH:52])[C@H:43]4[OH:53])[C:17]3([CH3:27])[CH3:28])=[O:11])[C@@H:7]1[CH2:6][C@:5]([C:56]([OH:58])=[O:57])([CH3:55])[CH2:4][CH2:3]2.[CH2:59]([NH2:62])[CH2:60][NH2:61]参加物
5
反応条件
- 温度
- 0 °C
実験手順
To N,N′-dimethylformamide (10 mL) were added glycyrrhetinic acid (1.0 mmol, 0.474 g) and ethylenediamine (30.0 mmol, 1.8 g, 2.0 mL). To the obtained solution were added dicyclohexyl carbodiimide (1.2 mmol, 0.247 g) and 4-N,N′-dimethylaminopyridine (catalytic amount) at 0° C. The mixture was stirred for 0.5-1 hour at 0° C. and then refluxed for further 12-48 hours. The resultant solution was filtered. To the filtrate was dropwise added diethyl ether. The precipitate was recovered and dried under vacuum to give glycyrrhetinic acid-ethylenediamine (yield=92%).
後処理
- temperaturerefluxed for further 12-48 hours
- filtrationThe resultant solution was filtered
- customThe precipitate was recovered
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-00b53f56056e4296abd143e2b0378110
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09173852B2
関連ノート
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