HCID 178452634、化合物 → HCID 178512234、化合物

HRID 705154ノート

反応式

HRID 705154 の反応式
[C:1]([N:3]=[C:4]([O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[NH:5][C:6]1[CH:7]=[CH:8][C:9]2[CH2:15][CH2:14][CH:13]([NH:16]C(OC(C)(C)C)=O)[CH2:12][CH2:11][C:10]=2[CH:24]=1)#[N:2]>C(O)(C)C.[H][H].[Pd]>[C:1]([N:3]=[C:4]([O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[NH:5][C:6]1[CH:7]=[CH:8][C:9]2[CH2:15][CH2:14][C@H:13]([NH2:16])[CH2:12][CH2:11][C:10]=2[CH:24]=1)#[N:2]

参加物

4

反応物 1

HCID 178452634HCID 178452634、化合物

生成物 1

HCID 178512234HCID 178512234、化合物

試薬・触媒・溶媒 2

HCID 178506449HCID 178506449、化合物触媒HCID 3776Isopropanol溶媒

実験手順

The single enantiomer was then BOC-protected, the nitro group reduced by treatment with H2/Pd and the primary aniline treated with diphenyl cyanocarboimidate (slight excess) in 20 mL of isopropanol with stirring at ambient temperature overnight. The solid was filtered, washed with isopropanol and ether and dried to give phenyl (7S) N′-cyano-N-(7-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-yl)carbamimidate, as a white solid in high yield (from the single enantiomer via transamination).

後処理

  1. filtrationThe solid was filtered
  2. washwashed with isopropanol and ether
  3. customdried

出典と根拠

ORDレコード
ord-e0ff593626f94e8b91b655a5a260e729
出典データセット
uspto-grants-2015_11
特許番号
US09173882B2

反応ノート

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