Phosphonic acid, P-(3-aminophenyl)- → N5-(3-phosphonophenyl)-L-glutamine

HRID 705453

反応式

HRID 705453 の反応式
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:8]([O:10]C(C)(C)C)=[O:9])[CH2:3][CH2:4][C:5](=[O:7])O.C1C=NC2N(O)N=NC=2C=1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[NH2:56][C:57]1[CH:58]=[C:59]([P:63](=[O:66])([OH:65])[OH:64])[CH:60]=[CH:61][CH:62]=1>CN(C=O)C.C(N(CC)CC)C>[P:63]([C:59]1[CH:58]=[C:57]([NH:56][C:5](=[O:7])[CH2:4][CH2:3][C@@H:2]([C:8]([OH:10])=[O:9])[NH2:1])[CH:62]=[CH:61][CH:60]=1)([OH:66])([OH:65])=[O:64]

参加物

7

反応物 4

HCID 79477Phosphonic acid, P-(3-aminophenyl)-HCID 181649HOAtHCID 6993444(4S)-5-(tert-butoxy)-4-{[(tert-butoxy)carbonyl]amino}-5-oxopentanoic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

生成物 1

HCID 45275687N5-(3-phosphonophenyl)-L-glutamine

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8471Triethylamine溶媒

実験手順

Boc-Glu-OtBu (236 mg, 0.78 mmol), HOAt (127 mg, 0.936 mmol) and HATU (356 mg, 0.936 mmol) were dissolved in 1 mL of DMF, and triethylamine (0.21 ml) was added thereto. 10 minutes later, the crude product of (3-aminophenyl)phosphonic acid was added thereto and stirred at room temperature overnight. After removing a solvent, purification was conducted in accordance with the purification process A to obtain a title compound.

後処理

  1. customAfter removing
  2. customa solvent, purification

出典と根拠

ORDレコード
ord-90529ef3f3ac4e118a6d7f25d21985b5
出典データセット
uspto-grants-2015_11
特許番号
US09174932B2

関連ノート

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