化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → 2,5-dichloro-3-(L-gamma-glutamylamino)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Chloramben-methyl | HCID 23714 | — |
| 反応物 | HOAt | HCID 181649 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 反応物 | Boc-Glu-OtBu hydrochloride | HCID 131731743 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2,5-dichloro-3-(L-gamma-glutamylamino)benzoic acid | HCID 66614819 | — |
反応手順
190 mg (0.5 mmol) of HATU, 70 mg (0.5 mmol) of HOAt, 152 mg (0.5 mmol) of Boc-Glu-OtBu hydrochloride, 0.21 mL (1.5 mmol) of triethylamine and 2 mL of dichloromethane were added to 110 mg (0.5 mmol) of methyl 2,5-dichloro-3-aminobenzoate, and stirred at room temperature overnight.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09174932B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-53d4b93c95af4e24bab72dc76517d40f |
| 出典メモ | uspto-grants-2015_11 |