Maleic Acid → HCID 67481355、化合物

反応式

[N:1]1([C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[N:12]=[C:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=[CH:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1.[C:22]([OH:29])(=[O:28])/[CH:23]=[CH:24]\[C:25]([OH:27])=[O:26]>C(O)(C)C.O>[C:22]([OH:29])(=[O:28])/[CH:23]=[CH:24]\[C:25]([OH:27])=[O:26].[N:1]1([C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[N:12]=[C:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=[CH:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1

参加物

反応条件

温度: 50 °C

実験手順

6-(1H-Imidazol-1-yl)-2-phenylquinazoline, 136 mg (0.5 mmol), is dissolved in a mixture of isopropanol (15 mL) and water (0.5 mL) at reflux, with stirring at 50° C., 60 mg (0.5 mmol) of maleic acid are added, the mixture is stirred for 30 min. at 40° C., and then cooled to 0° C., and the resulting suspension is stirred at 0° C. a few minutes, filtered, washed with cold isopropanol and dried at 30° C., 20 mmHg, for 5 hours. 120 mg of product are obtained, XRPD: form A+form B as in FIG. 51.