Phosphoric Acid → HCID 49857753、化合物
反応式
[N:1]1([C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[N:12]=[C:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=[CH:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1.[P:22](=[O:26])([OH:25])([OH:24])[OH:23]>CCO>[P:22]([OH:26])([OH:25])([OH:24])=[O:23].[N:1]1([C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[N:12]=[C:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=[CH:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1参加物
4
実験手順
6-(1H-Imidazol-1-yl)-2-phenylquinazoline, 275 mg (1 mmol), is dissolved in EtOH (15 mL) at reflux, 100 mg (1 mmol) of phosphoric acid are added, the mixture is stirred for 30 min., and is then allowed to cool to room temperature and left to stand for 3 days while allowing the solution to evaporate slowly, and the resulting material is filtered and dried at 30° C., 20 mmHg, for 8 hours. 270 mg of product are obtained, XRPD: Form A. TGA: no weight loss up to 250° C. Calculated for C17H12N4.H3PO4: C, 48.59; H, 4.13; N, 15.84. found: C, 57.22; H, 4.22; N, 15.84; H-NMR (d6-DMSO) δ: 9.72 (s, 1H), 8.60-8.50 (m, 2H), 8.48 (d, 1H), 8.41 (d, 1H), 8.23 (d, 1H), 8.21 (s, 1H), 7.98-7.58 (m, 3H), 7.22 (s, 1H).