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tert-Butyl (triphenylphosphoranylidene) acetate → Tert-butyl 3-(6-bromo-2-methoxypyridin-3-yl)acrylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl (triphenylphosphoranylidene) acetate | HCID 256127 | — |
| 反応物 | 6-Bromo-2-methoxynicotinaldehyde | HCID 12269213 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | Tert-butyl 3-(6-bromo-2-methoxypyridin-3-yl)acrylate | HCID 86658007 | 100% |
反応手順
(tert-Butoxycarbonylmethylene)triphenylphosphorane (1.74 g) was added to a solution of 6-bromo-2-methoxynicotinaldehyde (500 mg) in chloroform (5 mL) under ice-cooling, followed by stirring for one hour. The solvent was evaporated from the reaction solution under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=9:1) to give tert-butyl 3-(6-bromo-2-methoxypyridin-3-yl)acrylate as a colorless oil (726 mg, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822503B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-0d67ace4cd5b44c18847e836ae37bb44 |
| 出典メモ | uspto-grants-2014_09 |