Water → HCID 58452602、化合物

HRID 70566

反応式

HRID 70566 の反応式
[OH-].[K+].Br[CH2:4][CH:5]([CH3:7])[CH3:6].[Br:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][OH:17])=[CH:11][CH:10]=1.O>CS(C)=O>[Br:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][O:17][CH2:4][CH:5]([CH3:7])[CH3:6])=[CH:11][CH:10]=1

参加物

6

反応物 4

HCID 962WaterHCID 65551-Bromo-2-methylpropaneHCID 14797Potassium HydroxideHCID 728512-(4-Bromophenyl)ethanol

生成物 1

HCID 58452602HCID 58452602、化合物収率 70%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

Potassium hydroxide (1.32 g) and 1-bromo-2-methylpropane (1.04 mL) were added to a solution of 2-(4-bromophenyl)ethylalcohol (140 μL) in dimethyl sulfoxide (2 mL), and the mixture was stirred at room temperature overnight. Water was added to the reaction solution, followed by extraction with dichloromethane. The organic layer was filtered through diatomaceous earth and the filtrate was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane only) to give the title compound as a colorless oil (180 mg, 70%).

後処理

  1. extractionfollowed by extraction with dichloromethane
  2. filtrationThe organic layer was filtered through diatomaceous earth
  3. customthe filtrate was evaporated under reduced pressure
  4. customThe residue was purified by silica gel column chromatography (hexane only)

出典と根拠

ORDレコード
ord-e7e49ce9aa2a40a69c28271e7938841f
出典データセット
uspto-grants-2014_09
特許番号
US08822503B2

関連ノート

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