Dimethylamine → (5-Methoxy-benzooxazol-2-yl)-dimethyl-amine

HRID 706231ノート

反応式

HRID 706231 の反応式
Cl[C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:5]=2[N:6]=1.[CH3:13][NH:14][CH3:15]>O>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:4]2[O:3][C:2]([N:14]([CH3:15])[CH3:13])=[N:6][C:5]=2[CH:7]=1

参加物

4

反応物 2

HCID 674DimethylamineHCID 118197122-Chloro-5-methoxy-1,3-benzoxazole

生成物 1

HCID 57344577(5-Methoxy-benzooxazol-2-yl)-dimethyl-amine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 2-chloro-5-methoxy-benzooxazole (1.52 g, 8.31 mmol) and a 40% solution of dimethylamine in water (15 mL) was refluxed for two hours before it was cooled to room temperature and partitioned between ethyl acetate and water. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo to give the title compound as a black oil (1.14 g): MS: (+) m/z 397.19 (M+1)

後処理

  1. custompartitioned between ethyl acetate and water
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-fc7d307fa3154de2a505344361e69955
出典データセット
uspto-grants-2015_11
特許番号
US09174976B2

反応ノート

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