化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → (4S,5R)-3-(1H-benzo[d]imidazol-6-yl)-4,5-diphenyloxazolidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1,2-Diaminocyclohexane | HCID 4610 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Bromobenzene-1,2-diamine | HCID 323593 | — |
| 反応物 | (4S,5R)-(-)-cis-4,5-Diphenyl-2-oxazolidinone | HCID 9859564 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 溶媒 | Formic Acid | HCID 284 | — |
| 生成物 | (4S,5R)-3-(1H-benzo[d]imidazol-6-yl)-4,5-diphenyloxazolidin-2-one | HCID 58229203 | — |
反応手順
The compound was synthesized starting from (4S,5R)-4,5-diphenyloxazolidin-2-one (0.479 g, 2 mmol), 4-bromobenzene-1,2-diamine (0.374 g, 2 mmol), copper(I) iodide (0.038 g, 0.2 mmol), potassium carbonate (0.553 g, 4 mmol), cyclohexane-1,2-diamine (0.024 mL, 0.2 mmol), 5N HCl (5.8 mL), formic acid (0.582 mL) as described in method 5 step D
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09173885B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-c4453aa6d619496b9d70cd250fabfabb |
| 出典メモ | uspto-grants-2015_11 |