Water → (5R)-5-{(E)-2-(5-chloro-6-methoxypyridin-2-yl)-2-[4-(propan-2-yl)phenyl]ethenyl}-1-(2,4-dimethoxybenzyl)pyrrolidin-2-one

反応式

Br[C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([Cl:10])=[CH:4][CH:3]=1.[F-].[Cs+].[CH3:13][O:14][C:15]1[CH:51]=[C:50]([O:52][CH3:53])[CH:49]=[CH:48][C:16]=1[CH2:17][N:18]1[C@@H:22](/[CH:23]=[C:24](\[C:38]2[CH:43]=[CH:42][C:41]([CH:44]([CH3:46])[CH3:45])=[CH:40][CH:39]=2)/[Sn](CCCC)(CCCC)CCCC)[CH2:21][CH2:20][C:19]1=[O:47].O>CN(C)C=O.[Cu](I)I.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C(OCC)(=O)C>[Cl:10][C:5]1[CH:4]=[CH:3][C:2](/[C:24](/[C:38]2[CH:39]=[CH:40][C:41]([CH:44]([CH3:46])[CH3:45])=[CH:42][CH:43]=2)=[CH:23]/[C@@H:22]2[N:18]([CH2:17][C:16]3[CH:48]=[CH:49][C:50]([O:52][CH3:53])=[CH:51][C:15]=3[O:14][CH3:13])[C:19](=[O:47])[CH2:20][CH2:21]2)=[N:7][C:6]=1[O:8][CH3:9]