Water → (5R)-5-[(E)-2-(4-tert-butylphenyl)-2-{5-(difluoromethoxy)-6-[(4-methoxybenzyl)oxy]-pyridin-2-yl}ethenyl]-1-(2,4-dimethoxybenzyl)pyrrolidin-2-one

反応式

[F:1][CH:2]([F:21])[O:3][C:4]1[C:5]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)=[N:6][C:7](I)=[CH:8][CH:9]=1.[F-].[Cs+].[C:24]([C:28]1[CH:33]=[CH:32][C:31](/[C:34](/[Sn](CCCC)(CCCC)CCCC)=[CH:35]\[C@@H:36]2[N:40]([CH2:41][C:42]3[CH:47]=[CH:46][C:45]([O:48][CH3:49])=[CH:44][C:43]=3[O:50][CH3:51])[C:39](=[O:52])[CH2:38][CH2:37]2)=[CH:30][CH:29]=1)([CH3:27])([CH3:26])[CH3:25].O>CN(C)C=O.[Cu](I)I.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C(OCC)(=O)C>[C:24]([C:28]1[CH:33]=[CH:32][C:31](/[C:34](/[C:7]2[CH:8]=[CH:9][C:4]([O:3][CH:2]([F:21])[F:1])=[C:5]([O:11][CH2:12][C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[N:6]=2)=[CH:35]\[C@@H:36]2[N:40]([CH2:41][C:42]3[CH:47]=[CH:46][C:45]([O:48][CH3:49])=[CH:44][C:43]=3[O:50][CH3:51])[C:39](=[O:52])[CH2:38][CH2:37]2)=[CH:30][CH:29]=1)([CH3:27])([CH3:25])[CH3:26]