Morpholine → 4-Morpholinobut-2-YN-1-OL

HRID 706886ノート

反応式

HRID 706886 の反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[CH2:8][C:9]#[C:10][CH2:11][OH:12]>C1(C)C=CC=CC=1>[O:4]1[CH2:5][CH2:6][N:1]([CH2:8][C:9]#[C:10][CH2:11][OH:12])[CH2:2][CH2:3]1

参加物

4

反応物 2

HCID 8083MorpholineHCID 2027752-Butyn-1-ol, 4-chloro-

生成物 1

HCID 31128494-Morpholinobut-2-YN-1-OL

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

反応条件

温度
85 °C

実験手順

To a solution of morpholine (4.36 g) in toluene (15 mL) was added 4-chlorobut-2-yn-1-ol (2.09 g) in toluene (5 mL). The solution was stirred at 85° C. for 3 hours. After cooling, the solid was filtered off. The filtrate was subjected to vacuum distillation to give the pure title compound.

後処理

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered off
  3. distillationThe filtrate was subjected to vacuum distillation

出典と根拠

ORDレコード
ord-a4e3f6ea8f03421d80b5432a65bb7814
出典データセット
uspto-grants-2015_11
特許番号
US09174982B2

反応ノート

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