Hydrochloric Acid → 1-(Oxan-4-yl)piperazine--hydrogen chloride (1/2)

HRID 706908ノート

反応式

HRID 706908 の反応式
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[ClH:20]>CCOCC>[ClH:20].[ClH:20].[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 46785855HCID 46785855、化合物

生成物 1

HCID 441204811-(Oxan-4-yl)piperazine--hydrogen chloride (1/2)

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of EXAMPLE 128A (3.92 g) in ether was added HCl (25 ml, 2M in ether) and the reaction mixture was stirred for 16 hours at room temperature. The solid product was filtered off, dried and used in next step without further purification.

後処理

  1. filtrationThe solid product was filtered off
  2. customdried
  3. customused in next step without further purification

出典と根拠

ORDレコード
ord-69371b879f1a4e08bbad7614f668a6f3
出典データセット
uspto-grants-2015_11
特許番号
US09174982B2

反応ノート

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