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2-Isocyanatothiophene → 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-thiophen-2-ylurea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Isocyanatothiophene | HCID 2776375 | — |
| 反応物 | 4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)aniline | HCID 45379087 | — |
| 生成物 | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-thiophen-2-ylurea | HCID 44513887 | — |
反応手順
Starting from 4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)aniline (60 mg, 0.17 mmoles) and 2-thienyl isocyanate (18 mg, 0.14 mmoles), the title compound was isolated as a grey solid after Silica gel column chromatography by eluting with 5% ethyl acetate: methanol. Yield: 12 mg (14%); (M+H)=470.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09174963B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-66011c98da8c4b888b3606c258027ec3 |
| 出典メモ | uspto-grants-2015_11 |