Hydrochloric Acid → HCID 67477378、化合物

HRID 707342ノート

反応式

HRID 707342 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[N:11]1[CH2:14][CH:13]([NH:15]C(=O)OC(C)(C)C)[CH2:12]1.[ClH:23]>>[ClH:23].[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[N:11]1[CH2:12][CH:13]([NH2:15])[CH2:14]1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 58547859HCID 58547859、化合物

生成物 1

HCID 67477378HCID 67477378、化合物収率 100%

実験手順

To tert-butyl (1-(quinolin-2-yl)azetidin-3-yl)-carbamate (1.14 g, 3.84 mmol) was added hydrogen chloride (4 M solution in methanol, 20 mL). The reaction mixture was stirred at room temperature for 1 hour. It was concentrated to give 1-(quinolin-2-yl)azetidin-3-amine hydrochloride (0.90 g, 3.84 mmol, 100% yield) which was used in the next step without further purification.

後処理

  1. concentrationIt was concentrated

出典と根拠

ORDレコード
ord-665a3c4677994070877a6fcc6b0059de
出典データセット
uspto-grants-2015_11
特許番号
US09174992B2

反応ノート

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