N-chlorosuccinamide → Pyridine-2-carboximidoyl chloride

HRID 707640ノート

反応式

HRID 707640 の反応式
C([C:3]1[C:4]([CH:9]=[N:10]O)=[N:5][CH:6]=[CH:7][CH:8]=1)C.[Cl:12]NC(=O)CCC(N)=O>CN(C=O)C>[N:5]1[CH:6]=[CH:7][CH:8]=[CH:3][C:4]=1[C:9]([Cl:12])=[NH:10]

参加物

4

反応物 2

HCID 15238416N-chlorosuccinamideHCID 136338061Ethyl 2-pyridin-aldoxime

生成物 1

HCID 23228227Pyridine-2-carboximidoyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
30 °C

実験手順

To a mixture of ethyl 2-pyridin-aldoxime (15 gm) and N-chlorosuccinamide (25 gm) in DMF (30 ml) was stirred at 30° C. over a period of 2 h. The reaction mixture was quenched with ice-cold water (150 ml). The suspension was filtered and the wet cake washed with small quantity of water to provide pure title compound in 7 gm quantity (55%) as a white solid.

後処理

  1. customThe reaction mixture was quenched with ice-cold water (150 ml)
  2. filtrationThe suspension was filtered
  3. washthe wet cake washed with small quantity of water

出典と根拠

ORDレコード
ord-b8551bfae5ee4eb1a2fb451ddede6637
出典データセット
uspto-grants-2015_11
特許番号
US09175031B2

反応ノート

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