Diethyl Ether → Picolinohydrazide

HRID 707646

反応式

HRID 707646 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([O:9]CC)=O.[NH2:12][NH2:13].C(OCC)C>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([NH:12][NH2:13])=[O:9]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 9321HydrazineHCID 17307Ethyl 2-pyridinecarboxylate

生成物 1

HCID 255881Picolinohydrazide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

A mixture of ethyl pyridin-2-carboxylate (90 gm) and hydrazine (60 gm) in ethanol (400 ml) was stirred at 80° C. over a period of 4 h. Solvent was evaporated under vacuum to provide a crude mass. The crude mass was stirred with diethyl ether and the suspension was filtered and the wet cake washed with small quantity of ethanol (50 ml) to provide title compound in 76 gm quantity (93%) as a white solid.

後処理

  1. customSolvent was evaporated under vacuum
  2. customto provide a crude mass
  3. filtrationthe suspension was filtered
  4. washthe wet cake washed with small quantity of ethanol (50 ml)

出典と根拠

ORDレコード
ord-8bbad074dac646a2af175a410fab39b2
出典データセット
uspto-grants-2015_11
特許番号
US09175031B2

関連ノート

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