Pyridine 2-aldoxime → Pyridine-2-carboximidoyl chloride

HRID 707652ノート

反応式

HRID 707652 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=[N:8]O.[Cl:10]NC(=O)CCC(N)=O>CN(C=O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([Cl:10])=[NH:8]

参加物

4

反応物 2

HCID 13395Pyridine 2-aldoximeHCID 15238416N-chlorosuccinamide

生成物 1

HCID 23228227Pyridine-2-carboximidoyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
30 °C

実験手順

To a mixture of pyridin-2-carbaldehyde-oxime (15 gm) and N-chlorosuccinamide (25 gm) in DMF (30 ml) was stirred at 30° C. over a period of 2 h. The reaction mixture was quenched with ice cold water (150 ml). The suspension was filtered and the wet cake washed with small quantity of water to provide pure title compound in 7 gm quantity (55%) as a white solid.

後処理

  1. customThe reaction mixture was quenched with ice cold water (150 ml)
  2. filtrationThe suspension was filtered
  3. washthe wet cake washed with small quantity of water

出典と根拠

ORDレコード
ord-139f8a6b12f24b56a6b32ee87fd3d9da
出典データセット
uspto-grants-2015_11
特許番号
US09175031B2

反応ノート

読み込み中…