Phosphorus oxychloride → HCID 86677056、化合物

関与物質

反応手順

Phosphorus oxychloride (50 ml) was added to 12-oxo-3,4,6,12-tetrahydro-1H-thiopyrano[4′,3′:4,5]pyrido[1,2-a]benzimidazole-5-carbonitrile (16 g), followed by heating under reflux for 3 hours. The reaction liquid was concentrated under reduced pressure and the residue was poured into ice-water. The precipitate was collected by filtration and washed with water to obtain 12-chloro-3,4-dihydro-1H-thiopyrano[4′,3′:4,5]pyrido[1,2-a]benzimidazole-5-carbonitrile (18 g).

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