N-Methyl-N-[(3R)-pyrrolidin-3-yl]acetamide → HCID 58203783、化合物
反応式
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:22]=[CH:21][C:9]3[C:10]4[N:11]=[C:12]([C:18](O)=[O:19])[S:13][C:14]=4[CH2:15][CH2:16][O:17][C:8]=3[CH:7]=2)[CH:3]=[N:2]1.[CH3:23][N:24]([C@@H:28]1[CH2:32][CH2:31][NH:30][CH2:29]1)[C:25](=[O:27])[CH3:26]>>[CH3:23][N:24]([C@@H:28]1[CH2:32][CH2:31][N:30]([C:18]([C:12]2[S:13][C:14]3[CH2:15][CH2:16][O:17][C:8]4[CH:7]=[C:6]([C:4]5[CH:3]=[N:2][NH:1][CH:5]=5)[CH:22]=[CH:21][C:9]=4[C:10]=3[N:11]=2)=[O:19])[CH2:29]1)[C:25](=[O:27])[CH3:26]参加物
3
実験手順
Following the procedure for 103, 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (50.0 mg, 0.2 mmol) was reacted with (R)—N-methyl-N-(pyrrolidin-3-yl)acetamide (1.2 equiv) to give 180 (24.3 mg, M+1 438.1)
出典と根拠
- ORDレコード
- ord-341848fa9b5c45cebdf1b968e2b5d45a
- 出典データセット
- uspto-grants-2015_11